Santa Isabel Vacation Packages 2026 from $824

Santa Isabel flight + hotel vacation packages

Price found within the past 48 hours. Click for updated prices.

Riande Aeropuerto Hotel & Casino

Tocumen Airport

$824

per person

Jan 14 - Jan 19

found 1 day ago

Roundtrip flight included

Baltimore (BWI) to Panama City (PTY)

This smoke-free resort features a casino, 2 indoor tennis courts, and a restaurant. Bring the family and enjoy the children's pool, playground, and kid-friendly dining. Enjoy the outdoor pool and free perks like full breakfast and valet parking.

Central Hotel Panama Casco Viejo

Casco Viejo

Save 100% on your flight

$1,402

per person

Nov 27 - Dec 3

found 1 day ago

Roundtrip flight included

Baltimore (BWI) to Panama City (PTY)

A full-service spa, 3 restaurants, and an outdoor pool are all featured at this Belle Époque hotel. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and valet parking. Enjoy the 24-hour gym and unwind at the bar/lounge and poolside bar.

Megapolis Hotel Panamá

San Francisco

Save 100% on your flight

$1,176

per person

Nov 27 - Dec 3

found 1 day ago

Roundtrip flight included

Baltimore (BWI) to Panama City (PTY)

This smoke-free hotel features a casino, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the business center, free WiFi in public areas, and free valet parking. Relax with a drink at one of the 3 bars/lounges and enjoy free perks like buffet breakfast and free self parking.

Hyatt Regency Panama City

Bella Vista

$1,191

per person

Nov 27 - Dec 3

found 1 day ago

Roundtrip flight included

Baltimore (BWI) to Panama City (PTY)

This luxury hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and airport shuttle. Relax with a drink at one of the 2 bars/lounges and enjoy perks like free valet parking.

Las Clementinas

Casco Viejo

$1,582

per person

Jan 3 - Jan 10

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

A restaurant and a bar/lounge are featured at this aparthotel. WiFi in public areas is free. Self parking, a terrace, and a garden are also offered.

Top Santa Isabel hotels deals

Private Ocean-Front Cabin with private bathroom on San Blas Island

Diablo Island Narganá Guna Yala

$188 nightly

$207 total

Oct 25 - Oct 26

Total with taxes and fees

This hotel features a restaurant, a garden, and a snack bar/deli. Enjoy the free local cuisine breakfast each morning.

Breakfast included

Restaurant

Cocoloco - Catamaran Lagoon 52F SAN BLAS

El Porvenir Narganá Guna Yala

$1,923 nightly

$2,127 total

Oct 28 - Oct 29

Total with taxes and fees

A restaurant and a bar/lounge are featured at this cruise ship. Guests will appreciate free perks like continental breakfast and WiFi in public areas. A coffee shop and a snack bar/deli are also provided.

Breakfast included

Free WiFi

Caribbean Haven Of Nature 'Preci Beach'

Nombre de Dios Colon

Get rates

This vacation home features an outdoor pool and a hot tub. A garden, laundry facilities, and barbecue grills are also on offer.

Pool

Hot Tub

Private wood Cabins on San Blas island - private bathroom

Wailidup Island Narganá Guna Yala

$131 nightly

$144 total

Nov 1 - Nov 2

Total with taxes and fees

A marina and a restaurant are featured at this smoke-free hotel. Enjoy the outdoor pool and free local cuisine breakfast each morning. You'll appreciate the area shuttle, terrace, and snack bar/deli.

Pool

Breakfast included

BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES

Santa Isabel Colon

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This villa features limo/town car service, a garden, and laundry facilities. Barbecue grills are provided for your convenience.

Kitchen

Washer

Caribbean getaway: beach cottage just on the sand

Palenque Provincia de Colón

$316 nightly

$316 total

Oct 26 - Oct 27

Total with taxes and fees

This cottage features a garden, laundry facilities, and barbecue grills.

Kitchen

Washer

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much are vacation packages to Santa Isabel?

You might be pleasantly surprised — you can recharge your batteries in Santa Isabel for a mere $824. At Travelocity, we save you time and money with our amazing vacation packages. With experiences, hotels and flights all in one place, why put it off?

Where can I get the best vacation package deals for Santa Isabel?

Travelocity is here to help you lock in an unbeatable Santa Isabel package deal. With 400 airlines and 1,000,000 properties worldwide, we're sure you'll be able to craft the perfect itinerary.

Why should I book my Santa Isabel vacation package via Travelocity?

With our Price Match Guarantee, we'll match any lower price you find. Add to that our 24/7 customer support and high-quality service and the vacation of your dreams is closer than ever before.

Can I save on my Santa Isabel car rental if I bundle it with a hotel or flight?

You certainly can — bundle your car, flight and hotel into a Santa Isabel vacation package and you'll save plenty. With so many things to do in and around Santa Isabel, that rental vehicle will make exploring a joy. Once you've settled into the driver's seat, get out on the wide open road and head to Miraflores Locks, a renowned attraction roughly 45 mi from Santa Isabel.

Which airport is best for Santa Isabel?

There are two choices for flying to Santa Isabel, starting with Tocumen Intl. Airport (PTY). It's about 35 mi from the center of the city, while Marcos A. Gelabert Intl. Airport (PAC) is 45 mi away from central Santa Isabel.